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卓双木

来源:澳门赌搏网站大全 发布时间:2019-09-26 浏览次数:654


  • 个人简介:

研究员/博士生导师/博士后合作导师,新加坡&美国麻省理工学院科研中心学者奖励计划入选者、福建省特殊支持高层次人才“双百计划”入选者、福建省杰出青年基金获得者。长期从事光子学与医学交叉的学科-医学光子新技术新方法研究。主持或参与973计划、863计划、国家级、省部级等科研项目30余项。迄今,共发表 SCI论文110余篇(SCI III56篇),所发表论文已被Nature PhotonicsPNAS等国际权威刊物正面引用1740余次 (Google Scholar)h-index指数24,授权国家发明专利8件。研究工作多次被同行认定为首次的创新成果,获福建省科学技术奖一等奖、福建省科学技术奖三等奖、中国青少年科技创新奖、福建运盛青年科技奖和福建青年科技奖等奖项。中国青年科技工作者协会基础专委会委员、福建师范大学校学术委员会委员、中国光学学会青年委员、全国青年光学论坛副主席。担任Journal of Electronics and Communication Engineering Research编委、International Journal of Orthopaedics编委、Stem Cells International客座编委,同时作为本领域主要学术刊物Optics LettersApplied Physics LettersOptics ExpressBiomedical Optics ExpressBiomaterialsEndoscopyNanoscaleSurgical EndoscopyJournal of Biomedical Optics等的审稿专家。

  • 研究方向

主要从事光子学与医学交叉的学科-医学光子新技术新方法方面的研究

  • 代表性论文

临床学代表性期刊

  1. D.X. Chen#, G. Chen#, W. Jiang#, M.T. Fu#, W.J. Liu , J. Sui, S.Y. Xu , Z. Liu, X.L. Zheng, L. Chi, D. Lin, K. Li, W. Chen, N. Zuo, J. Lu, J.X. Chen, G.X. Li, S.M. Zhuo (卓双木)*, and J. Yan*, “Association of the collagen signature in the tumor microenvironment with lymph node metastasis in early gastric cancer,” JAMA Surgery, 154(3): e185249, 2019. (IF= 8.498, 美国医学会杂志子刊,外科学顶级期刊)

  2. J. Yan#*, X.L. Zheng#, Z. Liu, W.J. Liu, D. Lin, D.X. Chen, K. Li, W. Jiang, Z. Li, N. Zuo, G. Chen, J.P. Lu, J.X. Chen, G.X. Li, C. Xu, S.M. Zhuo (卓双木), “Multiphoton imaging provides a superior optical biopsy to that of confocal laser endomicroscopy imaging for colorectal lesions,” Endoscopy, 51(02), 174-178, 2019. (IF= 6.629, 欧洲消化内镜协会会刊)

  3. X.L. Zheng#, N. Zuo#, H.X. Lin, L.Q. Zheng, M. Ni, G.Z. Wu*, J.X. Chen, and S.M. Zhuo (卓双木)*, “Margin diagnosis for endoscopic submucosal dissection of early gastric cancer using multiphoton microscopy,” Surgical Endoscopy, https://doi.org/10.1007/s00464-019-06783-1, 2019. (IF=3.256, 美国胃肠道内镜外科医学会会刊)

  4. K. Gupta#, Q.S. Li#, J.J. Fan#, E.L.S. Fong, Z.W. Song, S.P. Mo, H.Y. Tang, I. C. Ng, C.W. Ng, P. Pawijit, S.M. Zhuo (卓双木), C.Y. Dong, B.C. Low, A. Wee, Y.Y. Dan, P. Kanchanawong, P.T.C. So, V. Viasnoff, and H. Yu*, “Actomyosin contractility drives bile regurgitation as an early response during obstructive cholestasis,” Journal of Hepatology, 66(6), 1231-1240, 2017. (IF= 15.040, 欧洲肝病学会会刊,肝病学顶级期刊)

  5. J.X. Chen*, S.M. Zhuo(卓双木), G. Chen, J. Yan, H.Q. Yang, N.R. Liu, L.Q. Zheng, X.S. Jiang, and S.S. Xie, “Establishing diagnostic features for identifying the mucosa and submucosa of normal and cancerous gastric tissues by multiphoton microscopy,” Gastrointestinal Endoscopy, 73, 802-807, 2011. (IF= 7.204, 美国胃肠内镜学会会刊)

  6. L. Fan, C.G. Lin, S.M. Zhuo(卓双木), L.L. Chen*, N. Liu, Y.K. Luo, J. Fang, Z.R. Huang, Y.L. Lin, and J.X. Chen, “Transplantation with survivin-engineered mesenchymal stem cells results in better prognosis in a rat model of myocardial infarction,” European Journal of Heart Failure, 11, 1023, 2009. (IF= 10.683, 欧洲心脏病学会会刊,心脏病学顶级期刊)

  7. J. Yan#*, S.M. Zhuo (卓双木) #*, G. Chen#, J.W. Milsom, H. Zhang, J. Lu, W. Zhu, S. Xie, J. Chen, and M. Ying, “Real-time optical diagnosis for surgical margin in low rectal cancer using multiphoton microscopy,” Surgical Endoscopy, 28, 36-41, 2014. (IF=3.256, 美国胃肠道内镜外科医学会会刊)

  8. J. Yan#*, G. Chen#, J.X. Chen#*, N.R. Liu, S.M. Zhuo (卓双木), H. Yu, and M.G. Ying, “A pilot study of using multiphoton microscopy to diagnose gastric cancer,” Surgical Endoscopy, 25, 1425-1430, 2011. (IF=3.256, 美国胃肠道内镜外科医学会会刊)

光学学科代表性期刊

  1. H.X. Lin#, L. Lin#, G.X. Wang, N. Zuo, Z.L. Zhan, S.S Xie, G. Chen, J.X. Chen, and S.M. Zhuo (卓双木)*, “Label-free classification of hepatocellular-carcinoma grading using second harmonic generation microscopy,”Biomedical Optics Express 9(8), 3783-3793, 2018. (IF=3.648, 美国光学学会期刊)

  2. H.X. Lin, C. Wei, G.X. Wang, H. Chen, L.S. Lin, M. Ni, J.X. Chen, , and S.M. Zhuo (卓双木)*, “Automated classification of hepatocellular carcinoma differentiation using multiphoton microscopy and deep learning,” Journal of Biophotonics, DOI: 10.1002/jbio.201800435, 2019. (IF=4.447, 欧洲光学学会期刊)

  3. M. Ning#*, S.M. Zhuo (卓双木)#*, C. Iliescu, P.T.C. So, J. S. Mehta, H. Yu*, and C. A. E. Hauser*, “Self-assembling amyloid-like peptides as exogenous second harmonic probes for bioimaging applications,” Journal of Biophotonics, DOI: 10.1002/jbio.201900065, 2019. (IF=4.447, 欧洲光学学会期刊)

  4. H.X. Lin, C. Wei, N. Cao, H. Chen, G.X. Wang, J.X. Chen, G.N. Chen*, and S.M. Zhuo (卓双木)*, “A novel low-signal image enhancement method for multiphoton microscopy,”J. Phys. D: Appl. Phys. 52, 285401, 2019. (IF=2.373, 英国皇家物理学会期刊)

  5. M. Ning*, S.M. Zhuo (卓双木)*, P.T.C. So, and H. Yu*, “Fluorescent Probes for Nanoscopy: Four Categories and Multiple Possibilities,” Journal of Biophotonics, 10, 11-23, 2017. (IF=4.447, 欧洲光学学会期刊)

  6. Q.W. Peng, S.M. Zhuo (卓双木)*, Peter TC So, and Hanry Yu*, “Improving liver fibrosis diagnosis based on forward and backward second harmonic generation signals,” Applied Physics Letters, 106, 083701, 2015. (IF=3.569,自然指数期刊)

  7. M Ni#*, and S.M. Zhuo (卓双木)#*, “Second harmonic generation microscopy for label-free imaging of fibrillar-like mesostructured polysulfone biomaterials,” Optical Materials Express, 5, 2692-2697, 2015. (IF=2.566, 美国光学学会期刊)

  8. S.M. Zhuo (卓双木)#*, Jie Yan#, Yuzhan Kang, Shuoyu Xu, Qiwen Peng, Peter TC So, and Hanry Yu*, “In vivo, label-free, three-dimensional quantitative imaging of liver surface using multi-photon microscopy,” Applied Physics Letters, 105, 023701, 2014. (IF=3.569, 自然指数期刊)

  9. S.M. Zhuo (卓双木), J.X. Chen*, G.Z. Wu, X.Q. Zhu, X.S. Jiang, and S.S. Xie*, “Label-free multiphoton imaging and photoablation of preinvasive cancer cells,” Applied Physics Letters, 100, 023703, 2012. (IF=3.569, 自然指数期刊)

  10. J.X. Chen#*, J. Xu#, D.Kang#, M. Xu, S.M. Zhuo (卓双木), X.Q. Zhu, and X.S. Jiang, “Multiphoton microscopic imaging of histological sections without hematoxylin and eosin staining differentiates carcinoma in situ from normal oesophagus,” Applied Physics Letters, 103, 183701, 2013. ( IF=3.569, 自然指数期刊)

  11. S.M. Zhuo (卓双木), L.Q. Zheng, J.X. Chen*, S.S. Xie*, X.Q. Zhu and X.S. Jiang, “Depth-cumulated epithelial redox ratio and stromal collagen quantity as quantitative intrinsic indicators for differentiating normal, inflammatory, and dysplastic epithelial tissues,” Applied Physics Letters, 97, 173701, 2010. (IF=3.569, 自然指数期刊)

  12. S.M. Zhuo (卓双木), J.X. Chen*, G.Z. Wu, S.S. Xie*, L.Q. Zheng, X.S. Jiang, and X.Q. Zhu, “Quantitatively linking collagen alteration and epithelial tumor progression by second harmonic generation microscopy,” Applied Physics Letters, 96, 213704, 2010. (IF=3.569, 自然指数期刊)

  13. S. Wang#, H.P. Du#, B.B. Lin#, C.X. Liao, X.Q. Zhu*, X.F. Wang, H. Chen, S.M. Zhuo (卓双木), L.W. Jiang, L.H. Li, H.H. Tu, and J.X. Chen*, “Spatial and temporal identification of cerebral infarctions based on multiphoton microscopic imaging,” Biomedical Optics Express 9(5), 2312-2325, 2018. ( IF=3.648, 美国光学学会期刊)

  14. J Xu#, D Kang#, Y Zeng#, S.M. Zhuo (卓双木), X Zhu, L Jiang, J.X. Chen*, and J. Lin*, “Multiphoton microscopy for label-free identification of intramural metastasis in human esophageal squamous cell carcinoma,” Biomedical Optics Express 8 (7), 3360-3368, 2017. (IF=3.648, 美国光学学会期刊)

  15. S.M. Zhuo (卓双木) #, J. Yan#, G. Chen#, J.X. Chen*, Y.C. Liu, J.P. Lu, X.Q. Zhu, X.S. Jiang, and S.S. Xie, “Label-free monitoring of colonic cancer progression using multiphoton microscopy,” Biomedical Optics Express, 2, 615, 2011. (IF=3.648, 美国光学学会期刊)

  16. S.M. Zhuo (卓双木), J.X. Chen*T.S. Luo, D.S. Zou, and J.J. Zhao, “Multimode nonlinear optical imaging of the dermis in ex vivo human skin based on the combination of multichannel mode and Lambda mode,” Optics Express, 14, 7810-7820, 2006. (IF=3.356, 美国光学学会期刊)

  17. S.M. Zhuo (卓双木), J.X. Chen*, S.S. Xie, Z.B. Hong, and X.S. Jiang, “Extracting diagnostic stromal organization features based on intrinsic two-photon excited fluorescence and second-harmonic generation signals,” Journal of Biomedical Optics. 14, 020503, 2009. (IF=2.859, 国际光学工程学会期刊)

  18. S.M. Zhuo (卓双木), J.X. Chen*, B.Y. Yu, X.S. Jiang, T. Luo, Q.G. Liu, R. Chen and S.S. Xie, “Nonlinear optical microscopy of the bronchus,” Journal of Biomedical Optics.13, 054024, 2008. (IF=2.859, 国际光学工程学会期刊)

  19. J. Yan#, S.M. Zhuo (卓双木) #*, G. Chen#, D. Zhou, S. Xie, J.H. Jiang, J. Fan, M.G. Ying, J.X. Chen, and J. Zhou*, “A preclinical study of using multiphoton microscopy to diagnose liver cancer and differentiate benign and malignant liver lesions,” Journal of Biomedical Optics, 17, 026004, 2012. (IF=2.859, 国际光学工程学会期刊)

  20. S.M. Zhuo (卓双木), X.Q. Zhu, G.Z. Wu, J.X. Chen*, and S.S. Xie, “Quantitative biomarkers of colonic dysplasia based on intrinsic second-harmonic generation signal,” Journal of Biomedical Optics, 16, 120501, 2011. (IF=2.859, 国际光学工程学会期刊)

  21. A.M. Raja, S. Xu, S.M. Zhuo (卓双木), D. Tai, W. Sun, P.T.C. So, R. Welsch, C.S. Chen, and H. Yu*, “Differential remodelling of extra-cellular matrices by breast cancer initiating cells,” Journal of Biophotonics. 8, 804-815, 2015. (IF=4.447, 欧洲光学学会期刊)

  22. S.Y. Xu#, C.H. Kang#, X. Gou, Q.W. Peng, J. Yan, S.M. Zhuo (卓双木), C.L. Cheng, Y.T. He, Y.Z. Kang, W.Z. Xia, Peter T. C. So, R. Welsch, J.C. Rajapakse, and H. Yu*, “Quantification of liver fibrosis via second harmonic imaging of the Glisson's capsule from liver surface,” Journal of Biophotonics, 9, 351-363, 2016. (IF=4.447, 欧洲光学学会期刊)

  • 获奖成果

  1. 卓双木,福建运盛青年科技奖,其他,20169

  2. 卓双木,福建青年科技奖,中共福建省委、福建省人事厅、福建省科学技术厅、福建省科学技术协会, 201111

  3. 陈建新、谢树森、卓双木、姜兴山、陈荣,基于非线性光谱成像新技术的医学无损诊断基础研究,福建省科学技术奖一等奖,福建省人民政府,20102

  4. 卓双木,中国青少年科技创新奖,共青团中央、全国青联、全国学联、全国少工委, 200912

  • 科研项目

  1. 国家自然科学基金面上项目,81771881,基于多光子显微技术的肝癌精准诊断及预后评估研究、2018/01-2021/1265.4万元,在研,主持。

  2. 福建省杰出青年基金滚动项目,2018J07004,肝癌精准诊断及预后评估的多光子显微新技术研究,2018/04-2021/0440万元,在研,主持。

  3. 广州市科技计划项目(产学研协同创新重大专项),201704020062,胃肠道肿瘤多光子成像的转化医学研究与光学活检设备的研发,2017/05-2020/0450万(总经费200万),在研,主持。

  4. 广东省自然科学基金(重大基础研究培育项目),SC-108,胃肠道肿瘤多光子成像基础及光学活检成像设备研究,2015/09-2019/0910万(总经费100万),在研,主持。

  5. 广东省科技计划项目(公益研究与能力建设专项),SC-132,利用高斯模型结合多光子技术创建移植肾间质纤维化精确分级系统的研究,2016/06-2019/0510万(总经费100万),已结题,主持。

  6. 福建省特殊支持高层次人才“双百计划”,2014年。

  7. 福建省杰出青年基金项目,2014J06016,基于多光子成像技术的肿瘤诊断及疗效评估研究,2014/01-2016/1225万元,已结题,主持。

  8. 福建省高等学校新世纪优秀人才支持计划,2013年。

  9. 国家自然科学基金面上项目,61275006,基于多光子成像技术的肿瘤基质研究、2013/01-2016/1280万元,已结题,主持。

  10. 福建省高校杰出青年科研人才培育计划,2012年。

  11. 新加坡&美国麻省理工学院研究中心, No.200711996H,学者奖励计划项目,2012/9-2014/9125万(25万新币),已结题,主持。

  12. 国家自然科学基金青年项目,60908043,多光子显微技术用于皮肤光老化诊断和治疗评估的研究,2010/01-2012/1221万元,已结题,主持。

  13. 国家973计划,2015CB352006,纳米分辨快速光学成像机理与技术的基础研究、2015/01-2019/123860万元,在研,参加。

  14. 国家自然基金重点项目,61335011,经穴效应细胞分子机理的光学表征,2014/01-2018/12280万,已结题,参加。

  15. 教育部“长江学者和创新团队发展计划”创新团队项目,IRT1115,“医学光电信息技术”方向,2012/01-2014/12300万,已结题,参加。

  16. 国家自然科学基金面上项目,81272574、多光子“光学活检”结合循环血肿瘤细胞在肝癌个体化治疗中的应用、2013/01-2013/1216万元,已结题,参加。

  17. 国家自然科学基金面上项目,30970783,鳞状上皮肿瘤早期无损诊断和治疗评估的非线性光谱成像技术,2010/01-2012/1232万元,已结题,参加。




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